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For the latest Hepatitis News, please scroll down.    

• 8/31 -  OIs and CA decline steeply after ART initiation; >1/3 of HOPS cohort who developed OI did so at CD4 counts at ≥200, threshold for OI prophy should be considered (HIV&Hepatitis)
• 8/31 - Male sex, family hx, smoking, ab lipids, and HTN predict atherosclerosis and CV events; TDF may have protective effect; D-dimer, VCAM-1, TIMP-1 linked to CVD; no link btw CVD and lower CD4 cell count (HIV&Hepatitis) 
• 8/31 - 31% of HIV+ people at risk for CVD may benefit from taking ASA QD; consider ASA as primary prevention rx (HIV&Hepatitis)
• 8/31 - PCP prophy may be d/c'd if VL <50 when CD4 is btw 101-200; incidence of PCP in this population was low irrespective of prophy use (HIV&Hepatitis)
• 8/31 - CNS serves as reservior for HIV even in VL <50; inflammation may persist despite ART; EFV suppressed HIV in brain faster than PI/r's; high dose IV IgG reduced latently infected CD4 cells in brain (HIV&Hepatitis) 
• 8/31 - A protein on rhesus macaques TRIM4a responsible for inhibiting HIV infection in species; ID may point way to future therapies using genetic engineering (HIV&Hepatitis) 
• 8/27 - Excessive immune activation, causing inflammation and premature exhaustion of immune cells.
• 8/27 - ART may reverse some of these changes, preventing non-AIDS conditions (HIV&Hepatitis) 
• 8/27 - PIE12-trimer, cell entry inhibitor, may be a candidate for a vaginal microbicide. It binds to the gp41 pocket conferring a higher barrier of resistance (HIV&Hepatitis) 
• 8/25 - HIV testing offered at home to household members of HIV-infected adults initiating ART associated with a 10-fold increased likelihood of testing. (aidsmap) 
• 8/25 - Breastfeeding is associated w/ significantly lower malaria incidence in HIV-exposed children; but protection fades w/ age. Recommend breastfeeding and co-trimoxazole prophy. (aidsmap)
• 8/24 - Precancerous anal cell changes in men common, regardless of VL and restored CD4 cells; invasive cervical cancer in women associated with lower CD4 cells (HIV&Hepatitis)  
• 8/24 - Sexual risk behaviour does not increase in IDUs who start HIV rx (aidsmap)
• 8/24 - Universal HIV testing followed by immediate initiation of ART for those infected could reduce transmission by 15-27%. Testing and linkage to care should part of a multi-pronged HIV prevention approach (HIV&Hepatitis) 
• 8/24 - IDUs, heavy alcohol users, individuals w/ mental health problems, people of color, women and transgender people were less likely to acheive undetectable VL and their all-cause mortality increased over time despite ART (HIV&Hepatitis)
• 8/24 - Decitabine and gemcitabine, anti-cancer rx, together reduced HIV infectivity by 75% in mice. Increased mutation frequency lead to "lethal mutagenesis" (HIV&Hepatitis) 
• Integrase promoter and SQV led to apoptosis of infected HIV cells. Non-infected cells not affected (HIV&Hepatitis) 
• 8/24 - Heroin use, AIDS, predict reduced bone mineral density in older men with HIV (aidsmap) 
• 8/20 - Rx-failures more likely w/ ≥1 drug-resistance mutation; PIs may be advisable if pre-rx genotypes not available (HIV&Hepatitis) 
• 8/20 - ETV has fewer neuropsychic side effects than EFV, switching may improve sx (HIV&Hepatitis) 
• 8/20 - Less than 1% of people w/ HIV for 15-y did not experience disease progression in the absence of ART. All but 10% required ART and only 0.25% were considered Controllers (HIV&Hepatitis) 
• 8/20 - DHHS Pediatric ART Guidelines released: new rating system, drug characteristic/info appendix, AE info in table format, dx of infants, when/what to start, and adherence (AIDSinfo) 
• 8/20 - Need for prevention campaigns reaching beyond gay community: MSM's 9% report are HIV+, 18% HSV-2+, < 1/2 reported themselves as gay (HIV&Hepatitis)

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For the latest HIV news, please scroll up. 

• 8/31 - Spontaneous clearing of HCV w/o rx has low risk (10% over 5 yrs) of death; CHC is at elevated risk of overall and liver-related mortality, including HCC (HIV&Hepatitis)
• 8/31 - PegIFN + RBV has high SVR in HCV+ children; 60% with HCV G1 & G4, and 90% with HCV G2 and 3 achieved cure (HIV&Hepatitis) 
• 8/27 - IL28B gene patter may influence susceptibility to HCV genotypes: CC IL28B significantly more common among non-1 HCV genotypes (HIV&Hepatitis) 
• 8/27 - The fittest HCV viruses had mutations in one region of the surface protein the virus uses to infect cells in new liver transplantation. Blocking this region may provide a new way to prevent reinfection (HIV&Hepatitis) 
• 8/27 - ADF plus LAM is better "rescue therapy" for LAM-resistant HBV, rather than switching to ETV (HIV&Hepatitis) 
• 8/24 - TDF and ETV for the rx of HBV are the most potent oral agents for HBeAg+ pts; TDF most effective for HB3Ag- pts (HIV&Hepatitis)
• 8/24 - TMC435 demonstrates potent antiviral activites in PILLAR study maintaining HCV SVR through 12-weeks (HIV&Hepatitis) 
• 8/24 - Neurocognitive effects previously reported in HIV/HCV may begin to happen soon after HCV acquisition (HIV&Hepatitis) 
• 8/20 - Silymarin, milk thistle extract, has an inhibitory effect on HCV, but may have cell entry blocking mechanism (HIV&Hepatitis) 
• 8/20 - Acute HCV in HIV+ men: HIV probably plays a critical role mediated either through behavioral and/or biological factors (HIV&Hepatitis)
• 8/19 - Genetic variation near the IL28B gene and aa substitution of the core region predict SVR to TPV/pegIFN/r (Hepatology) 

• [2010/8/31] Mutation Predicts Response to HCV Therapy in Co-In...
  HIV-positive people with a certain mutation in the gene that makes interleukin-28B are more likely to respond to stand...
• [2010/8/31] Vitamin A Boosts Levels of HIV in Breast Milk.
  Vitamin A and beta-carotene supplements are unsafe for HIV-positive women who breastfeed because they may boost the ex...
• [2010/8/27] Fatigue Common in HIV+ People, Linked to Psycholog...
  HIV-related fatigue has a high prevalence (up to 88% in some studies) and is strongly associated with depression ...
• [2010/8/27] Study Suggests HIV Hides in CNS
  A Swedish study of patients with undetectable plasma viral loads on ART found that 10% showed traces of HIV in sp...
• [2010/8/23] Gene Therapy for HIV Shows Positive Results in Mice
  Researchers at Sangamo BioSciences testing a gene therapy approach for attacking HIV have reported in Nature Biotechno...
• [2010/8/23] Smoking Poses Health Threat to HIV+ Patients
  Smoking prevalence is higher in HIV+ patients than in the general population, so investigators studied the effect of s...

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