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Therapy for Life: Improving the Treatment of Antiretroviral-Naive Patients

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Jointly Sponsored by:

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About the Program

Program Overview

The construction of an ARV treatment regimen that maximizes the patient's chance for successful ARV therapy and minimizes the short- and long-term risk of morbidity and mortality is complex. Clinicians caring for HIV-positive patients need to understand the importance of selecting - and have the ability and knowledge to select - an ARV regimen that maximizes the patient's chance for virologic success and a long, healthy life. This requires that the clinician have (1) a familiarity with the clinical research assessing ART in ART-naïve patients, (2) an understanding of the complex factors involved in ARV selection, and (3) an ability to assess the needs and abilities of the individual patient so care can be individualized. 

This highly interactive, case-based program will provide clinicians of varying knowledge and skill levels with the requisite knowledge and clinical skills they need to choose the best regimen for each patient and is designed to address educational gaps that limit effective ARV therapy from being provided to HIV-positive patients.

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Program Objectives

Upon completion of the program, participants will demonstrate the ability to:

  • Discuss key clinical research evaluating ART regimens and strategies in ART-naïve patients;

  • Use data regarding ARV tolerance, adverse events, resistance barriers, pharmacokinetics, and other issues to improve initial ART success rates;

  • Explain the role individual patient characteristics or desires may play in selecting initial ART;

  • Select ART regimens that maximize each patient's chance of long-term success.

Release Date: October 19, 2010
Expiration Date: October 18, 2011

Estimated time to complete the activity: 2 hours

Media: Internet

Commercial Support Acknowledgement

This activity is supported by an unrestricted educational grant from Merck & Co., Inc.

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Target Audience

This activity is intended for physicians, physicians' assistants, advanced practice nurses, and other health care professionals actively involved in the treatment and management of patients with HIV-infection. It is tuition-free and there are no prerequisites.

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Course Directors

Calvin J. Cohen, MD, MS
Research Director,
CRI New England
Clinical Instructor,
Harvard Medical School
Boston, Massachusetts

Joseph Eron, MD
Professor,
University of North Carolina School of Medicine
Chapel Hill, North Carolina
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Faculty

Edwin DeJesus, MD
Medical Director,
Orlando Immunology Center
Orlando, Florida   
Trevor Hawkins, MD
Associate Professor, University of New Mexico
Medical Director, Southwest CARE Center
Santa Fe, New Mexico

Richard A. Elion , MD
Associate Professor of Clinical Medicine,
George Washington University Medical Center
Washington, DC

Ian Frank, MD
Professor of Medicine,
Director, Antiretroviral Clinical Research
University of Pennsylvania
Philadelphia, Pennsylvania 

David Wohl, MD
Associate Professor of Medicine,
Division of Infectious Diseases, School of Medicine,
The University of North Carolina, Chapel Hill
Co-Director of HIV Services for the North Carolina
Department of Corrections
Chapel Hill, North Carolina
 
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Enduring Web Program 

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Accreditation Statement

This activity has been planned and implemented in accordance with the Essential Areas and Policies of the Accreditation Council for Continuing Medical Education (ACCME) through the joint sponsorship of Postgraduate Institute for Medicine (PIM) and ViralEd. PIM is accredited by the ACCME to provide continuing medical education for physicians.

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Credit Designation Statement

Postgraduate Institute for Medicine designates this educational activity for a maximum of 2.0 AMA PRA Category 1 Credit(s)TM. Physicians should only claim credit commensurate with the extent of their participation in the activity.

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Disclosure of Conflicts of Interest

Postgraduate Institute for Medicine (PIM) assesses conflicts of interest with its instructors, planners, managers and other individuals who are in a position to control the content of CME activities. All relevant conflicts of interest that are identified are thoroughly vetted by PIM for fair balance, scientific objectivity of studies utilized in this activity, and patient care recommendations.PIM is committed to providing its learners with high quality CME activities and related materials that promote improvements or quality in health care and not a specific proprietary business interest of a commercial interest.

The faculty reported the following financial relationships or relationships to products or devices they or their spouse/life partner have with commercial interests related to the content of these CME activities:

Calvin Cohen, MD:

  • Contracted Research: Gilead; Bristol-Myers Squibb; Merck & Co.; Tibotec; ViiV
  • Consulting Fees: Gilead; Bristol-Myers Squibb; Merck & Co.; Tibotec; Abbott
  • Speakers Bureau: Gilead; Bristol-Myers Squibb; Merck & Co.; Tibotec

Edwin DeJesus, MD

  • Contracted Research: Abbott; Achillion; Avexa; Boehringer Ingelheim; Bristol-Myers Squibb; Gilead; GlaxoSmithKline; Hoffman LaRoche; Merck; Pfizer; Schering Plough; Taimed; Tobira; Tibotec; Vertex
  • Consulting Fees: Bristol-Myers Squibb; Gilead; GlaxoSmithKline; Merck; Tibotec; Vertex
  • Speakers Bureau: Gilead Sciences; Tibotec; Virco

Richard Elion, MD

  • Contracted Research: Gilead; Bristol-Myers Squibb; Merck & Co.; Tibotec; GlaxoSmithKline; Rapid
  • Consulting Fees: Gilead; Bristol-Myers Squibb; GlaxoSmithKline; Tibotec
  • Speakers Bureau: Gilead; Bristol-Myers Squibb; GlaxoSmithKline; Tibotec

Joseph Eron, MD:

  • Contracted Research: Merck, GlaxoSmithKline, TaiMed
  • Consulting Fees: Merck, Avexa, BMS, GSK, Tibotec, Virco Laboratories, Pfizer, Tobira, Chimerix, Myriad, Inhibitex
  • Speakers' Bureau/Honorarium: Roche, BMS, Virco Laboratories

Ian Frank, MD:

  • Contracted Research: GlaxoSmithKline, Merck & Co.
  • Consulting Fees: Gilead; Tibotec, Bristol-Meyers Squibb
  • Speakers Bureau: Gilead; Tibotec

Trevor Hawkins, MD

  • Contracted Research: Gilead; GlaxoSmithKline
  • Consulting Fees: Gilead; Tibotec
  • Speakers Bureau: Gilead; Bristol-Myers Squibb; Merck & Co.; Tibotec

David Wohl, MD

  • Consulting Fees: Abbott, Tibotec, Gilead
  • Contracted Research: Merck, GSK, Tibotec, Gilead
  • Fees for non-CME/CE Services: Gilead, Abbott, Tibotec, Bristol-Meyers Squibb, Merck
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Disclosure of Unlabeled Use

This educational activity may contain discussion of published and/or investigational uses of agents that are not indicated by the FDA. Postgraduate Institute for Medicine (PIM), ViralEd, LLC, and Merck & Co., Inc. do not recommend the use of any agent outside of the labeled indications.

The opinions expressed in the educational activity are those of the faculty and do not necessarily represent the views of PIM, ViralEd, LLC, and Merck. Please refer to the official prescribing information for each product for discussion of approved indications, contraindications, and warnings.

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Instructions for Participation and Credit 

There are no fees for participating and receiving credit for this activity. During the period, October 19, 2010 through October 18, 2011 participants must 1) read the learning objectives and faculty disclosures; 2) study the educational activity; and 3) complete the post-test and evaluation form.

To answer the questions, click on your selected choice for each answer then proceed to the next question. We recommend that you print a copy of your answers before you submit them to us. Once completed, click on the Submit Post-test at the bottom of the page. Your post-test will automatically be graded.

If you successfully complete the post-test (score of 70% or higher). your certificate will be made available immediately.  Click on View Certificate and print the certificate for your records.  If you received a score of 69% or less, you will receive a message notifying you that you did not pass the post-test.  You may retake the post-test until successful.

You may complete the Post-test on-line at http://www.cmeuniversity.com/.

  • Click on "Find Post-Test/Evaluation by Course" on the navigation menu

  • Search by project ID 7025

  • Upon successfully completing the Post-test and Evaluation form, your certificate will be made available immediately.

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Disclaimer

Participants have an implied responsibility to use the newly acquired information to enhance patient outcomes and their own professional development. The information presented in this activity is not meant to serve as a guideline for patient management. Any procedures, medications, or other courses of diagnosis or treatment discussed or suggested in this activity should not be used by clinicians without evaluation of their patient's conditions and possible contraindications on dangers in use, review of any applicable manufacturer's product information, and comparison with recommendations of other authorities.

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